CoQ10 is a component of the mitochondria and plays a key role in the synthesis of ATP. Ubiquinol is the activated form of CoQ10. B vitamins are important cofactors needed to fuel the Krebs cycle, while optimal serum levels of magnesium are associated with healthy mitochondrial metabolism and nutrient transport. Acetyl-l-carnitine provides carnitine to transport long chain fatty acids into the mitochondria for energy as well as an acetyl group for the synthesis of the Krebs cycle precursor acetyl-CoA. Highly pure creatine monohydrate helps enhance the production of the ATP by acting as a precursor. This formula provides antioxidant support from vitamins C and E, as well as additional antioxidant support from grape seed extract, resveratrol, alpha lipoic acid and n-acetyl-l-cysteine. These nutrients and bioactives may neutralize the free radicals generated during energy production in the mitochondria. In a double-blind, placebo-controlled crossover study, the combination of creatine, CoQ10, and alpha lipoic acid supported energy production and antioxidant status within the mitochondria.