Inositol Complex 60’s

Verifiable Science

Inositol is a component of the B-complex family. The predominant form of inositol in the body and central nervous system is myo-inositol. Myo-inositol plays an important role in cell membrane formation and serves as part of the phosphatidylinositol second messenger system, supporting serotonin, norepinephrine and cholinergic receptor function.¹ Optimal levels of inositol have been associated with positive mood, emotional wellness and help lessen occasional nervous tension.² D-chiro inositol is another isomer with distinct functions in the body from myo-inositol. Both forms act as second messengers to support healthy insulin signaling, however, D-chiro inositol also helps promote the cellular response to insulin.³ D-chiro inositol also plays a role in maintaining healthy androgen metabolism.⁴ The combination of myo-inositol and D-chiro inositol helps to support healthy ovarian function and reproductive system function. Studies suggest that the ratio of myo-inositol and D-chiro inositol influences clinical effects. The ratio varies considerably across different tissues, ranging from 2:1 in the liver, 200:1 in the brain and heart, 100:1 in the follicular fluid, and 40:1 in the blood.² Studies have utilized ratios ranging from 0.4:1 to 104:1 of D- chiro inositol:myo-inositol.³ A 2019 comparison study suggests that a 3.6:1 ratio of myo-inositol:D- chiro inositol supports reproductive function when compared to an alternate (40:1) ratio. Twelve weeks of supplementation with 550 mg myo-inositol and 150 mg D-chiro inositol twice daily (3.6:1 ratio) was found to offer support for oocyte quality and healthy pregnancy.⁵ Two additional studies indicate that supplementation with a 3.6:1 myo-inositol:D-chiro inositol ratio for 6 months supported healthy menstrual regularity, luteinizing hormone/follicle- stimulating hormone (LH/FSH) ratios and glucose homeostasis.^6,7