Nitric Oxide Ultra (capsules) offers a blend of CranLoad and citrulline to support healthy blood flow by targeting nitric oxide production and flow-mediated dilation. The formula centers around CranLoad, a novel fruit blend developed as part of an extensive research program with the Institute of Nutrition and Functional Foods (INAF) and Universite Laval in Quebec, Canada. CranLoad delivers a unique cranberry and grape seed blend that has been the subject of several trials. Cranberries and grapes are particularly generous sources of proanthocyanidins and other polyphenols. In addition to being antioxidants, these compounds offer specific vascular support mechanisms that are associated with enhanced endothelial function. Research indicates that CranLoad may provide statistically significant support for healthy flow-mediated dilation (FMD), an effect similar to arginine administration. A similar physiological effect may have been demonstrated with arginine. Citrulline is included to support nitric oxide production in the blood vessel endothelium and other tissues. Research indicates that citrulline may increase plasma arginine in a dose-dependent manner and to a greater degree than arginine supplementation.