Enhances the expression and function of insulin receptors with the natural plant alkaloid berberine. In a randomized, placebo-controlled trial involving 116 subjects, berberine provided statistically significant support for healthy glucose and lipid metabolism. Promotes healthy AMPK and SIRT1 protein levels to support cellular metabolism and glucose homeostasis with resveratrol. In a recent randomized, double-blind, placebo-controlled, 4-week study, resveratrol supported healthy insulin signaling and antioxidant defenses. Modulates cell signaling for healthy insulin function with patent-pending Zychrome chromium dinicocysteinate. In a randomized, placebo-controlled trial, Zychrome supported healthy glucose metabolism and offered statistically significant support for antioxidant defenses as measured by TNFÎ±. Supports healthy receptor function and glucose metabolism with alpha lipoic acid.