Supports immune balance and tissue integrity, in part by targeting the NLRPs (NOD-like receptor proteins) and NF-κB pathways to modulate cytokine production; NLRPs act as intracellular sensors to oxidative and environmental stressors. Promotes numerous enzyme and gene transcription pathways including SIRT1 and Nrf2. Promotes the health of joint, G.I. and thyroid tissue that is influenced by immunological factors. Balanced Immune is designed to support immune balance and tissue integrity, in part by targeting the NLRP and NF-κB pathways to modulate cytokine production. NLRP (NOD-like receptor proteins) act as intracellular sensors to oxidative and environmental stressors. Research suggests curcumin and vitamin D support healthy cellular response, in part by modulating this pathway. The formula also promotes numerous enzyme and gene transcription pathways targeting nutrient metabolism in the liver, detoxification, and cellular protection against oxidative stress. Black ginger and resveratrol promote healthy SIRT1 protein levels. SIRT1 supports cellular homeostasis, plays an important role in insulin secretion and glucose homeostasis, and affects glucose and lipid metabolism in the liver. In a double-blind, placebo-controlled, crossover study, 100 mg of Sirtmax black ginger extract for seven weeks supported healthy glucose metabolism and weight management, while in vitro studies on its active constituents suggest a five-fold increase in SIRT1 activity compared to resveratrol. Sulforaphane and resveratrol support the activity of Nrf2, a transcription factor that supports cellular function by promoting cellular detoxification and protection against oxidative stress.